Since the U.S. Food and Drug Administration approved proton therapy to treat patients in 1988, the medical community has conducted research on the use of protons in treating different types of cancer through clinical trials.
Over the years, many patients have volunteered to take part in these clinical trials to help find improvements in fighting cancer with proton therapy. Our site alone has enrolled over 1,200 patients in clinical research studies, and we are 1 of 3 centers that participate in a registry devoted to pediatric proton therapy research.
We offer approximately 14 active research protocols for adults and many more for children to help advance clinical standards for proton therapy.
- BRE007-12 Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer: The purpose of this research study is to compare the effects (good and bad) on women and their cancer using proton radiation therapy.
ClinicalTrials.gov Identifier: NCT01766297
- BRE008-12 Proton Radiation for Stage II/III Breast Cancer: The purpose of this study is to look at the rates of acute and long-term adverse events of postoperative proton radiotherapy for complex logo-regional irradiation in women with loco-regionally advanced breast cancer. This study specifically includes longitudinal follow-up to assess the incidence of cardiac mortality and second malignant neoplasms at 10 and 15 years following proton therapy (PT).
ClinicalTrials.gov Identifier: NCT01758445
- NCT02603341 Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients With Non-Metastatic Breast Cancer: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial: A pragmatic randomized clinical trial of patients with locally advanced breast cancer randomized to either proton or photon therapy and followed longitudinally for cardiovascular morbidity and mortality, health-related quality of life and cancer control outcomes. Quality of life is the outcome measure for the estimated primary completion date of November, 2020.
ClinicalTrials.gov Identifier: NCT02603341
- NRG BN001 Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma: This randomized phase II trial studies how well dose-escalated photon intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy works compared with standard-dose radiation therapy when given with temozolomide in patients with newly diagnosed glioblastoma.
ClinicalTrials.gov Identifier: NCT02179086
- NRG BN005 A Phase II Randomized Trial of Proton vs. Photon Therapy (IMRT) for Cognitive Preservation in Patients With IDH Mutant, Low to Intermediate Grade Gliomas: This randomized phase II clinical trial studies the side effects and how well proton beam or intensity-modulated radiation therapy works in preserving brain function in patients with IDH mutant grade II or III glioma.
ClinicalTrials.gov Identifier: NCT03180502
- LUN005-12 A Phase I/II Study of Hypofractionated Proton Therapy for Stage II-III Non-Small Cell Lung Cancer: The purpose of this research study is to compare the effects (good and bad) on subjects and their cancer using standard chemotherapy in combination with hypofractionated proton radiation therapy. Hypofractionation is a technique that delivers higher daily doses of radiation over a shorter period of time.
ClinicalTrials.gov Identifier: NCT01770418
- RTOG 1308 Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung Cancer: This randomized phase III trial studies proton chemoradiotherapy to see how well it works compared to photon chemoradiotherapy in treating patients with stage II-III non-small cell lung cancer that cannot be removed by surgery.
ClinicalTrials.gov Identifier: NCT01993810